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Table 2 Biodistribution of 99mTc-HYNIC-Annexin-V in EL4 lymphoma and the number of apoptotic cells after single-dose irradiations

From: In vivo99mTc-HYNIC-annexin V imaging of early tumor apoptosis in mice after single dose irradiation

   Dose (Gy)    p  
  0 2 4 8 0 vs.2 2 vs.4 4 vs.8
%ID/g 0.160 ± 0.013 0.272 ± 0.021 0.312 ± 0.020 0.355 ± 0.025 <0.001 0.017 0.009
T/B 0.729 ± 0.037 1.252 ± 0.086 1.396 ± 0.021 1.661 ± 0.072 <0.001 0.005 <0.001
T/M 2.575 ± 0.154 4.522 ± 0.554 5.191 ± 0.511 7.138 ± 0.266 <0.001 0.039 <0.001
Apoptotic cells 1.405 ± 0.191 2.459 ± 0.370 4.364 ± 0.778 6.953 ± 0.673 0.002 0.004 0.002
  1. Results expressed as mean ± SD. %ID/g = percentage injected dose per gram of tumor tissue; T: 99mTc-HYNIC annexin-V uptake in tumor; B: 99mTc-HYNIC-annexin V uptake in blood; M: 99mTc-HYNIC annexin-V uptake in muscle. Apoptotic cells were counted as the number of TUNEL positive cells per mm2 of each examined section.