ERCC2, ERCC1 polymorphisms and haplotypes, cooking oil fume and lung adenocarcinoma risk in Chinese non-smoking females

Table 2 ERCC2 751, 312 and ERCC1 188 polymorphisms and lung adenocarcinoma risk

Genotype	Cases n (%)	Controls n (%)	OR [95%CI]^a	P value
ERCC2 751
AA	220 (77.2)	242 (84.9)	1.00	--
AC	61 (21.4)	40 (14.0)	1.66 [1.07-2.59]	0.024
CC	4 (1.4)	3 (1.1)	1.28 [0.28-5.86]	0.751
AC/CC^b	65 (22.8)	43 (15.1)	1.64 [1.06-2.52]	0.025
ERCC2 312
GG	246 (86.3)	255 (89.5)	1.00	--
GA	38 (13.3)	30 (10.5)	1.30 [0.78-2.17]	0.317
AA	1 (0.4)	0 (0.0)	--^e	--
GA/AA^c	39 (13.7)	30 (10.5)	1.33 [0.80-2.21]	0.275
ERCC1 118
CC	156 (54.7)	176 (61.8)	1.00	--
CT	104 (36.5)	96 (33.6)	1.19 [0.84-1.70]	0.334
TT	25 (8.8)	13 (4.6)	2.01 [0.99-4.10]	0.054
CT/TT^d	129 (45.3)	109 (38.2)	1.29 [0.92-1.81]	0.139

Abbreviation: OR, odds ratio; CI, confidence interval.
^aORs were calculated by unconditional logistic regression and adjusted for age and cooking oil fume.
^bOR and P value were calculated compared with wild genotype(AA) of ERCC2 751 polymorphism.
^cOR and P value were calculated compared with wild genotype(GG) of ERCC2 312 polymorphism.
^dOR and P value were calculated compared with wild genotype(CC) of ERCC1 118 polymorphism.
^eOR and P value for this genotype could not be calculated.

ISSN: 1756-9966