Table 1 Modena Model
From: Subjective versus objective risk in genetic counseling for hereditary breast and/or ovarian cancers
High risk | Pedigree Classification | |||
|---|---|---|---|---|
I) at least 3 relatives diagnosed with BC (or OC) in 2 different generations | II) one BC/OC case is a first degree relative of the other 2 (of the other 1 if the first criterion is not fulfilled)° | III) at lest one case has been diagnosed at the age ≤ 40 or with bilateral BC |  |  |
* | * | * | Hereditary | HBC/HBOC |
* | * | Â | Suspect Hereditary | SHBC/SHBOC |
* | Â | * | Suspect Hereditary | SHBC/SHBOC |
BC diagnosed at age ≤ 35, regardless of family history | Early onset | EOBC | ||
BC and OC in the same woman, regardless of family history | Breast and Ovarian Cancer | BOC | ||
Intermediate Risk | ||||
* | Â | Â | Familial | FBC/FBOC |
| Â | * | * | Strongly suspected Familial | SFBC/SFBOC |
Male BC, regardless of family history | Male Breast Cancer | MBC | ||
Slightly Increased Risk | ||||
| Â | * | Â | Suspected Familial | SFBC/SFBOC |
| Â | Â | * | Suspected Familial | SFBC/SFBOC |
BC/OC without any of the described criteria | Sporadic Breast Cancer | SpBC/SpOC | ||