Tissue microarray analysis of eIF4E and its downstream effector proteins in human breast cancer

Table 2 Lack of correlation of ER, PR, or HER-2/neu with eIF4E

		95% Confidence Interval
	Rho Value	Lower	Upper	n	P
TMA expression of eIF4E ^a
eIF4E and ER	-0.137	-0.469	0.228	31	0.452
eIF4E and PR	-0.069	-0.413	0.293	31	0.707
eIF4E and HER-2/neu	-0.013	-0.406	0.384	25	0.949
Western blot expression of eIF4E ^b
eIF4E and ER	-0.192	-0.479	0.132	39	0.237
eIF4E and PR	-0.295	-0.558	0.023	39	0.069
eIF4E and HER-2/neu	-0.143	-0.469	0.216	32	0.425

^a For the first three rows, comparisons were made of immunohistochemical staining of each protein normalized to cytokeratin to ER, PR, and HER-2/neu. ^bLast three rows, comparison of protein expression of eIF4E assayed by western blot (fold- over benign) to ER, PR, and HER-2/neu. All comparisons were done using Spearman's Rank Correlation.

ISSN: 1756-9966