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Table 4 The effects of paclitaxel on deoxycytdine kinase and cytidine deaminase activity and gene expression in solid tumor cell lines

From: Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines

Cell line H460 H520 H838
Deoxycytidine kinase (dCK)
Control 0.46 ± 0.12 1.23 ± 0.12 2.44 ± 1.56
Paclitaxel 0.69 ± 0.14 1.67 ± 0.25 2.60 ± 0.46
Fold change 1.5 1.4a 1.1
Cytidine deaminase (CDA)
Control 11.8 ± 3.4 18.2 ± 10.5 4.1 ± 2.1
Paclitaxel 27.0 ± 16.1 31.9 ± 11.1 10.4 ± 6.8
Fold change 2.3 1.8a 2.5
  1. Mean (± standard deviation) of the activity of deoxycytidine kinase (nmol per hour per 106 cells) or cytidine deaminase (pmol per minute per 106 cells) after exposure to vehicle-control or paclitaxel for 24 hours. The mean represents three independent experiments with each experiment conducted in at least triplicate. The fold change represents the mean activity after exposure to paclitaxel divided by the mean activity after exposure to vehicle-control.
  2. a P < 0.05 or P < 0.001, paclitaxel vs control-treated cells