The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma

Table 1 Correlation of expression of VEGF-C, VEGF-D, and Flt-4 in cervical cancer tissues with clinicopathological parameters

Variables	n	VEGF-C			VEGF-D			Flt-4
		(+)	(-)	P	(+)	(-)	P	(+)	(-)	P
Catamenia
Premenopause	68	37	31	NS	42	26	NS	33	35	NS
Postmenopause	29	19	10		17	12		18	11
Tumor size (cm)
≤4	61	36	25	NS	35	26	NS	30	31	NS
>4	36	20	16		24	12		21	15
Stromal invasion
≤2/3	40	22	18	NS	27	13	NS	24	16	NS
>2/3	57	34	23		32	25		27	30
FIGO stage
I a	16	10	6	NS	7	9	NS	9	7
I b	33	18	15		22	11		18	15
II a	48	28	20		30	18		24	24
Histological grade										NS
HG₁	21	9	12	NS	12	9	NS	10	11
HG₂	31	18	13		20	11		15	16
HG₃	45	29	16		27	18		26	19
Lymph node metastasis
Negative	67	33	34	0.012	35	32	0.010	30	37	0.022
Positive	30	23	7		24	6		21	9
LVI
Negative	39	16	23	0.006	18	21	0.015	14	25	0.007
Positive	58	40	18		41	17		37	21
Histological cell type
SCC	81	46	35	NS	50	31	NS	43	38	NS
ADE	16	10	6		9	7		8	8

Abbreviations: HG, histological grade; LVI, lymphatic vessel invasion; SCC, squamous cell carcinoma; and ADE, adenocarcinoma. P, chi-square test.

ISSN: 1756-9966