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Table 1 Correlation of expression of VEGF-C, VEGF-D, and Flt-4 in cervical cancer tissues with clinicopathological parameters

From: The role of VEGF-C/D and Flt-4 in the lymphatic metastasis of early-stage invasive cervical carcinoma

Variables n VEGF-C VEGF-D Flt-4
   (+) (-) P (+) (-) P (+) (-) P
Catamenia           
   Premenopause 68 37 31 NS 42 26 NS 33 35 NS
   Postmenopause 29 19 10   17 12   18 11  
Tumor size (cm)           
   ≤4 61 36 25 NS 35 26 NS 30 31 NS
   >4 36 20 16   24 12   21 15  
Stromal invasion           
   ≤2/3 40 22 18 NS 27 13 NS 24 16 NS
   >2/3 57 34 23   32 25   27 30  
FIGO stage           
   I a 16 10 6 NS 7 9 NS 9 7  
   I b 33 18 15   22 11   18 15  
   II a 48 28 20   30 18   24 24  
Histological grade           NS
   HG1 21 9 12 NS 12 9 NS 10 11  
   HG2 31 18 13   20 11   15 16  
   HG3 45 29 16   27 18   26 19  
Lymph node metastasis           
   Negative 67 33 34 0.012 35 32 0.010 30 37 0.022
   Positive 30 23 7   24 6   21 9  
LVI           
   Negative 39 16 23 0.006 18 21 0.015 14 25 0.007
   Positive 58 40 18   41 17   37 21  
Histological cell type           
   SCC 81 46 35 NS 50 31 NS 43 38 NS
   ADE 16 10 6   9 7   8 8  
  1. Abbreviations: HG, histological grade; LVI, lymphatic vessel invasion; SCC, squamous cell carcinoma; and ADE, adenocarcinoma. P, chi-square test.