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Table 1 Combination index values

From: Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer

OVCAR-3

  

Concentration of Drugs

CI value

Interpretation

Zoledronic acid (5 μM) + ATRA (80 nM)

0.688

Synergism

Zoledronic acid (10 μM) + ATRA (80 nM)

0.705

Synergism

MDAH-2774

  

Concentration of Drugs

CI value

Interpretation

Zoledronic acid (5 μM) + ATRA (40 nM)

0.010

Synergism

Zoledronic acid (5 μM) + ATRA (80 nM)

0.009

Synergism

  1. Combination index values of ATRA and zoledronic acid alone and in combination in OVCAR-3 and MDAH-2774 cells. CI values were calculated from the XTT cell viability assays. The data represent the mean of three independent experiments
  2. CI a: Combination index
  3. ATRA*: All trans retinoic acid