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Table 1 Combination index values

From: Enhancing cytotoxic and apoptotic effect in OVCAR-3 and MDAH-2774 cells with all-trans retinoic acid and zoledronic acid: a paradigm of synergistic molecular targeting treatment for ovarian cancer

OVCAR-3   
Concentration of Drugs CI value Interpretation
Zoledronic acid (5 μM) + ATRA (80 nM) 0.688 Synergism
Zoledronic acid (10 μM) + ATRA (80 nM) 0.705 Synergism
MDAH-2774   
Concentration of Drugs CI value Interpretation
Zoledronic acid (5 μM) + ATRA (40 nM) 0.010 Synergism
Zoledronic acid (5 μM) + ATRA (80 nM) 0.009 Synergism
  1. Combination index values of ATRA and zoledronic acid alone and in combination in OVCAR-3 and MDAH-2774 cells. CI values were calculated from the XTT cell viability assays. The data represent the mean of three independent experiments
  2. CI a: Combination index
  3. ATRA*: All trans retinoic acid