Figure 5From: Reduction of lung metastasis, cell invasion, and adhesion in mouse melanoma by statin-induced blockade of the Rho/Rho-associated coiled-coil-containing protein kinase pathwayInhibitory effect of oral administration of statins on lung metastasis. B16BL6 cells were injected into the tail veins of syngeneic C57BL/6J mice. Mice were treated daily from days 1 to 14 with 10 mg/kg fluvastatin or simvastatin. After 14 d, visible nodules that had metastasized to the lungs were counted. The results are expressed as the mean ± SD for 9 mice.Back to article page