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Table 2 Phenotypic changes on human NK cells after 14 days of expansion

From: Ex-vivo expanded human NK cells express activating receptors that mediate cytotoxicity of allogeneic and autologous cancer cell lines by direct recognition and antibody directed cellular cytotoxicity

  Healthy donors (n = 6) Patient 1 Patient 2
  Day 0 Day 14      
  Mean (%) Range (%) Mean (%) Range (%) P-valuea, b(%) Day 0 Day 14 Day 0 Day 14
Activating receptors
DNAM-1 83 72-90 94 89-97 0.0335 (↑) 90 97 37 90
NKG2D 83 51-98 96 93-99 0.1074 30 94 87 98
NKp46 68 27-91 87 64-97 0.0161 (↑) 52 95 19 70
NKp44 3 2-5 59 16-93 0.0039 (↑) 0,3 29 0,4 15
NKp30 52 11-93 82 67-97 0.0131 (↑) 7 63 15 70
Inhibitory receptors
KLRD1 68 56-82 92 86-95 0.0012 (↑) ND 98 49 95
NKG2A 46 14-67 68 34-89 0.00118 (↑) ND 84 7 8
KIR3DL1 22 10-37 29 17-38 0.1526 ND 21 5 3
KIR3DL2/3 28 9-48 29 14-44 0.7858 ND 35 88 96
LIR1 22 13-37 6 3-9 0.0142 (↓) ND 18 70 44
  1. a Significant differences (P < 0.05) are indicated in bold
  2. b Arrows indicate significant increase (↑) or significant decrease (↓)
  3. ND; not determined