Table 2 Phenotypic changes on human NK cells after 14 days of expansion
| Â | Healthy donors (n = 6) | Patient 1 | Patient 2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Day 0 | Day 14 | Â | Â | Â | Â | Â | ||
| Â | Mean (%) | Range (%) | Mean (%) | Range (%) | P-valuea, b(%) | Day 0 | Day 14 | Day 0 | Day 14 |
Activating receptors | |||||||||
DNAM-1 | 83 | 72-90 | 94 | 89-97 | 0.0335 (↑) | 90 | 97 | 37 | 90 |
NKG2D | 83 | 51-98 | 96 | 93-99 | 0.1074 | 30 | 94 | 87 | 98 |
NKp46 | 68 | 27-91 | 87 | 64-97 | 0.0161 (↑) | 52 | 95 | 19 | 70 |
NKp44 | 3 | 2-5 | 59 | 16-93 | 0.0039 (↑) | 0,3 | 29 | 0,4 | 15 |
NKp30 | 52 | 11-93 | 82 | 67-97 | 0.0131 (↑) | 7 | 63 | 15 | 70 |
Inhibitory receptors | |||||||||
KLRD1 | 68 | 56-82 | 92 | 86-95 | 0.0012 (↑) | ND | 98 | 49 | 95 |
NKG2A | 46 | 14-67 | 68 | 34-89 | 0.00118 (↑) | ND | 84 | 7 | 8 |
KIR3DL1 | 22 | 10-37 | 29 | 17-38 | 0.1526 | ND | 21 | 5 | 3 |
KIR3DL2/3 | 28 | 9-48 | 29 | 14-44 | 0.7858 | ND | 35 | 88 | 96 |
LIR1 | 22 | 13-37 | 6 | 3-9 | 0.0142 (↓) | ND | 18 | 70 | 44 |