Figure 5

Histological examination and immunohischemistry analysis of tumors xenografts in athymic nude mice. A Representative areas are shown (× 200 magnification). Histological appearance of tumor tissue from CNE-2Z-inoculated athymic mice with or without PI3K inhibitor treatment (Left: no treatment group; Right: treatment with 75 mg/kg LY2940020). B Expression of p-Akt in the tumor tissue with or without PI3K inhibitor treatment (Left: no treatment group; Right: treatment with 75 mg/kg LY2940020). C Expression of Ki67 in the tumor tissue with or without PI3K inhibitor treatment (Left: no treatment group; Right: treatment with 75 mg/kg LY2940020). D Expression of caspase-9 in the tumor tissue with or without PI3K inhibitor treatment (Left: no treatment group; Right: treatment with 75 mg/kg LY2940020).