Figure 6
Inhibition of tumor growth in tumor-bearing mice by immunization with MAGE-1-modified, CCL3 and CCL20-recruited DC vaccine. (A), Each of 10 mice in a group was challenged s.c. with 1 × 105 viable MFC tumor cells. Mice were subsequently injected s.c. with DC-Ad-MAGE-1 5 days later. As controls, tumor-bearing mice were injected with DC-Ad-LacZ, DC-MFC Ag, or untreated DCs. Survival was observed over time after immunization of mice harboring preexisting tumors. Survival rate was compared with a long-rank test of Kaplan-Meier curves. (B), Tumor growth was measured every 2~3 days after the second immunization. Data are given as means ± SD of 10 mice per group from three independent experiments.