Figure 1

Results of gene cluster analysis. Genes were clustered according to type of changes in expression in particular cell lines (SK-N-BE(2) or SH-SY5Y) after combined treatment with ATRA and particular inhibitors (CA or CX). ATRA was applied in concentrations of 1 or 10 μM (1 ATRA, 10 ATRA); CA in concentrations of 13 and 52 μM (13 CA, 52 CA), and CX in concentrations of 10 and 50 μM (10 CX, 50 CX). The green color at the farthest left end of the color scale corresponds to the minimal value; the red color at the farthest right end of the color scale corresponds to the maximal value; and the black color in the middle of the color scale corresponds to the average value. Each of the other values corresponds to a certain color according to its magnitude. The colors are assigned according to the value of the particular gene expression in all samples in the respective experimental variant (I, II, III or IV).