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Table 2 Ultrastaging of sentinel lymph node using H&E, serial sectioning and IHC in patients with cervical cancer

From: Ultrastaging of lymph node in uterine cancers

Study Year Method of analysis Nb of patients FIGO stage Macrometastatic SLN (%) Micrometastatic SLN (%)
Lantzsch 2001 H&E +SS+IHC 14 IB1 1 (7.1) 0
Plante 2003 H&E +SS+IHC 70 IA-IIA 8 (13.1) 3 (37.5)
Dargent 2003 H&E +SS+IHC 70 IA1-IIB 19 (30.2) 9 (47.4)
Hubalewska 2003 H&E +SS+IHC 37 I-IIA 5 (13.5) na
Pijpers 2004 H&E +SS+IHC 34 early 12 (36.3) 4 (33)
Silva 2005 H&E +SS+IHC 56 IA2-IIA 17 (32.7) 3 (17.6)
Rob 2005 H&E +SS+IHC 183 IA2-IB2 35 (21.9) na
Angioli 2005 H&E +SS+IHC 37 IB1 6 (23) 0
Di Stefano 2005 H&E +SS+IHC 50 IA2-IIA 9 (20) 2 (22.2)
Frumovitz 2006 H&E +SS+IHC 50 IA2-IB1 9 (18.8) na
Wang 2006 H&E +SS+IHC+CK19PCR 46 early 18 (39) 7 (38.9)
Yuan 2007 H&E +SS+IHC 81 IB1-IIA 17(20.9) 4 (23.5)
Coutant 2007 H&E +SS+IHC+HPV DNA 59 IA-II 15 (25.4) 3 (20)
Lee 2007 H&E +HPV DNA 57 IB-IIA 11 (19.3) na
Hauspy 2007 H&E +SS+IHC 39 IA1-IIA 2 (5.2) na
Bats 2007 H&E +SS+IHC 25 IA2-IA1 3 (12) 1 (33)
Total    908   187 (20.6) 36 (19.2)
  1. SLN: sentinel lymph node; H&E: hematein eosin staining; IHC: immunohistochemy; SS: serial sectioning; HPV: human papilloma virus; na: not available