Figure 1

Pancreatic cancer cell growth was detected by MTT assay. SW1990 and Capan-2 cells growing in 96-well plates were treated with AG490 and interleukin-6 (IL-6), respectively, for 24, 48 and 72 hours. Incubation with 20 μM/L AG490 for 72 hours markedly reduced proliferation of SW1990 cells (P = 0.000), but incubation with 20 μM/L AG490 for 24, 48 hours did not reduce proliferation of SW1990 cells (P = 0.051, P = 0.060). Incubation with 100 ng/ml IL-6 for 48 and 72 hours increased proliferation of Capan-2 cells significantly (P = 0.001, P = 0.000) , but incubation with 100 ng/ml IL-6 for for 24 hours did not increase proliferation of SW1990 cells (P = 0.073). Data are mean ± SD of 8 wells. A = Absorbance.