Figure 3
Expression of cyclin D1 in mammary glands and spontaneous breast cancer tissues from TA2 mice. 3A, Cyclin D1 staining could be observed occasionally in epithelial cells from five month-old TA2 mice (IHC, 200×). 3B, Cyclin D1 staining was present in the nuclei of epithelial cells in mammary gland tissues of spontaneous breast cancer-bearing TA2 mice (IHC, 200×). 3C, Cyclin D1 staining was present in the nuclei of hyperplastic epithelial cells of spontaneous breast cancer-bearing TA2 mice (IHC, 200×). 3D, Cyclin D1 staining was also present in spontaneous breast cancer tissues of TA2 mice (IHC, 200×). The Labeling Index of cyclin D1 increased apparently from Group A to Group C.