The association of 18F-deoxyglucose (FDG) uptake of PET with polymorphisms in the glucose transporter gene (SLC2A1) and hypoxia-related genes (HIF1A, VEGFA, APEX1) in non-small cell lung cancer. SLC2A1 polymorphisms and FDG-PET in NSCLC patients

Table 5 Association between the SLC2A1 -2841A>T gene polymorphism and the mean SUVmax in patients with squamous cell carcinoma according to the APEX1 genotype

APEX1 genotype	Gene	genotype	SUVmax	P*	Dominant model	SUVmax	P ^†	Recessive mode	SUVmax	P ^†
TT	SLC2A1 -2841A>T	AA (n = 13)	8.68 ± 2.40	0.086	AA	8.68 ± 2.40	0.742	AA + AT	8.46 ± 2.90	0.028
		AT (n = 12)	8.22 ± 3.47		AT + TT	9.07 ± 3.58		TT	12.47 ± 1.33
		TT (n = 3)	12.47 ± 1.33
TG	SLC2A1 -2841A>T	AA (n = 20)	9.72 ± 3.00	0.984	AA	9.72 ± 3.00	0.857	AA + AT	9.66 ± 2.93	0.932
		AT (n = 9)	9.53 ± 2.94		AT + TT	9.54 ± 2.56		TT	9.54 ± 2.00
		TT (n = 5)	9.54 ± 2.01
GG	SLC2A1 -2841A>T	AA (n = 8)	9.81 ± 1.97		AA	9.81 ± 1.97	0.134	AA + AT	8.97 ± 2.23
		AT (n = 8)	8.13 ± 2.26		AT + TT	8.13 ± 2.26		TT
		TT (n = 0)

ISSN: 1756-9966