Figure 2
From: Anti-tumor activity of N-trimethyl chitosan-encapsulated camptothecin in a mouse melanoma model
Induction of apoptosis on B16-F10 cells by CPT-TMC in vitro. Cellular apoptosis was verified by flow cytometric analysis. B16-F10 Cells were treated with (a) media-only, (b) TMC, (c) CPT, or (d) CPT-TMC, respectively. It is clear that the number of apoptotic cells in CPT-TMC and CPT treated group was significantly higher compared with other two groups. The apoptotic rate showed 62% in CPT-TMC-treated group versus 57.1% in CPT-treated group, 10% in TMC-treated group and 3.9% in media-only-treated group.