Table 1 Clinically Relevant KIT Mutations
From: Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors
KIT Genotype | Mutation Type | Domain |
|---|---|---|
Primary activating mutations | ||
Δ552-559 | Deletion | Juxtamembrane domain |
V560D | Single mutation | Juxtamembrane domain |
AYins503-504 | Insertion | Extracellular domain |
Secondary imatinib-refractory mutations | ||
D816V | Single mutation | Activation loop |
Y823D | Single mutation | Activation loop |
V560D/V654A | Double mutation | Juxtamembrane domain/kinase domain I |
V560D/T670I | Double mutation | Juxtamembrane domain/kinase domain I |