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Table 1 Clinically Relevant KIT Mutations

From: Motesanib inhibits Kit mutations associated with gastrointestinal stromal tumors

KIT Genotype Mutation Type Domain
Primary activating mutations   
   Δ552-559 Deletion Juxtamembrane domain
   V560D Single mutation Juxtamembrane domain
   AYins503-504 Insertion Extracellular domain
Secondary imatinib-refractory mutations   
   D816V Single mutation Activation loop
   Y823D Single mutation Activation loop
   V560D/V654A Double mutation Juxtamembrane domain/kinase domain I
   V560D/T670I Double mutation Juxtamembrane domain/kinase domain I