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Table 3 HER2 expression in relation to main tumor cheracteristics and treatment response

From: Evaluation of HER2 and p53 expression in predicting response to docetaxel-based first-line chemotherapy in advanced breast cancer

 

HER2 expression"

 

Total

Low

High

p value

Age

    

   < 55 yrs

18

13

5

n.s.

   ≥55 yrs

18

14

4

 

ER expression

    

   Negative

14

10

4

n.s.

   Positive

22

17

5

 

PgR expression

    

   Negative

13

9

4

n.s.

   Positive

23

18

5

 

Grading #

    

   G2

21

18

3

0.05

   G3

15

8

7

 

Stage*°

    

   I-IIA

17

16

1

0.003

   IIB-III

16

8

8

 

Ki67

    

   Negative

22

18

4

n.s.

   Positive

14

9

5

 

Treatment response

    

   CR+PR

15

9

6

0.046

   SD+PD

21

18

3

 
  1. "IHC 0, 1+ and 2+ FISH negative were regarded as negative while IHC 3+ or 2+ FISH positive were regarded as positive. #According to Elston and Ellis classification (see text for complete reference). *According to UICC-TNM classification of malignant tumours, sixth edition 2002. °At initial diagnosis time. n.s. = not significant; CR = complete response; PR = partial response; SD = stable disease; PD = disease progression.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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