Table 1 Association of COX-2 expression in NSCLC with clinical and pathologic factors (χ2 test)
Total | COX-2 low expression n(%) | COX-2 high expression n(%) | P | |
|---|---|---|---|---|
Sex | ||||
Male | 63 | 33 (52.4) | 30 (47.6) | 0.803 |
Female | 21 | 12 (57.1) | 9 (42.9) | |
Age | ||||
≤60 years | 44 | 23 (52.3) | 21 (47.7) | 0.830 |
> 60 years | 40 | 22 (55.0) | 18 (45.0) | |
Smoking | ||||
Yes | 38 | 21 (55.3) | 17 (44.7) | 0.828 |
No | 46 | 24 (52.2) | 22 (47.8) | |
Differentiation | ||||
Well and moderate | 40 | 20 (50.0) | 20 (50.0) | 0.662 |
Poor | 44 | 25 (56.8) | 19 (43.2) | |
TNM stage | ||||
I | 44 | 21 (47.7) | 23 (52.3) | 0.357 |
II | 19 | 10 (52.6) | 9 (47.4) | |
III + IV | 21 | 14 (66.7) | 7 (33.3) | |
Histology | ||||
Adeno | 34 | 18 (52.9) | 16 (47.1) | 0.561 |
SCC | 45 | 23 (51.1) | 22 (48.9) | |
Large cell carcinoma | 5 | 4 (80.0) | 1 (20.0) | |
VEGF expression | ||||
High | 42 | 12 (28.6) | 30 (71.4) | 0.000 |
Low | 42 | 33 (78.6) | 9 (21.4) | |
MVD expression | ||||
High | 28 | 10 (35.7) | 18 (64.3) | 0.036 |
Low | 56 | 35 (62.5) | 21 (37.5) |