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Table 2 Multivariate analysis of VEGF and MVD expression in NSCLC specimens

From: Cyclooxygenase-2 up-regulates vascular endothelial growth factor via a protein kinase C pathway in non-small cell lung cancer

   VEGF expression    MVD expression  
  β HR (95% CI) P β HR (95% CI) P
COX-2 expression       
   High 2.286 9.836 (3.387 - 28.564) 0.000 1.146 3.147 (1.152 - 8.598) 0.025
   Low 1.000    1.000   
TNM stage       
   III + IV 0.061 1.063 (0.493 - 2.289) 0.877 0.025 1.025 (0.493 - 2.132) 0.947
   I + II 1.000    1.000   
Histology       
   Adeno -0.300 0.741 (0.303 - 1.810) 0.510 0.400 1.491 (0.649 - 3.425) 0.346
   SCC 1.000    1.000   
Differentiation       
   Poor -0.292 0.746 (0.198 - 2.809) 0.665 -0.969 0.379 (0.106 - 1.359) 0.137
   Well and moderate 1.000    1.000   
Smoking       
   Yes -0.775 0.461 (0.145 - 1.461) 0.188 -0.481 0.618 (0.214 - 1.785) 0.374
   No 1.000    1.000   
Sex       
   Male -1.005 0.366 (0.101 - 1.330) 0.127 -0.511 0.600 (0.170 - 2.110) 0.426
   Female 1.000    1.000   
Age       
   ≥ 60 yrs 0.316 1.371 (0.413 - 4.551) 0.606 -0.223 0.800 (0.251 - 2.551) 0.706
   < 60 yrs 1.000    1.000   
  1. Abbreviations: HR, hazard ratio; CI, confidence interval of the estimated HR; Adeno, adenocarcinoma; SCC, squamous cell carcinoma