Platinum resistance in breast and ovarian cancer cell lines

Table 1 Comparison of Cisplatin resistance in vitro models of A2780 ovarian cancer cells and MCF-7 breast-cancer cells

	altered in Cisplatin resistant
Read-out	MCF-7 CisR	A2780 CisR
Cisplatin resistance factor	3.3***	5.8***
proliferation rate [%]	192**	55.3***
invasive capacity [%] compared to parental cells	153.7*	129.5*
RTK activation in Cisplatin resistant cells	EGFR/ERB-B2	IGF-1R
autocrine growth factor	amphiregulin	IGF-1
bystander effect	no	IGF-1 mediated
ERK1,2 activation	elevated	elevated
p38 activation	no	p38α
JNK activation	no	no
AKT kinase activation	elevated	elevated

An overview of the long-term functional and biochemical changes after establishment of Cisplatin resistance is given. Cisplatin resistant breast cancer cells and ovarian cancer cells were compared to their non-resistant parental cells. Denoted are the changes observed in the Cisplatin resistant situation [64, 72].

ISSN: 1756-9966