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Table 1 Distribution of CYP1A1 MspI and exon7 genotypes among lung cancer cases and controls included in this meta-analysis

From: CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review

First author-year Ethnicity(country of origin) Total sample size
(case/control)
Lung cancer cases
of MspI genotype
Controls of
MspI genotype
Lung cancer cases
of exon7 genotype
Controls of exon7 genotype
    Type B Type C Type A Type B Type C Type A Ile/Val Val/Val Ile/Ile Ile/Val Val/Val Ile/Ile
Kawajiri K-1990 Asia(Japan) 68/104 28 16 24 42 11 51 NA NA NA NA NA NA
Tefre T-1991 Caucasian(Norway) 221/212 47 2 172 43 2 167 NA NA NA NA NA NA
Hirvonen A-1992 Caucasian(Finnish) 87/121 22 0 65 24 2 95 NA NA NA NA NA NA
Shields PG-1993 Mixed populations 56/48 11 2 43 12 3 33 NA NA NA NA NA NA
Nakachi K-1993 Asia(Japan) 31/127 7 13 11 55 11 61 11 6 14 44 4 79
Alexandrie AK-1994 Caucasian(Sweden) 296/329 44 4 248 52 1 276 16 0 280 23 0 306
Kelsey K.T -1994 Mixed(African Americans) 72/97 11 1 60 21 2 74 NA NA NA NA NA NA
Cantlay AM-1995 Caucasian(Edinburgh) 129/281 NA NA NA NA NA NA 21 2 106 33 3 245
Kihara M-1995 Asia(Japan) 97/258 45 16 36 105 41 112 31 5 59 98 14 143
Xu XP-1996 Caucasian(USA) 207/238 35 2 170 48 2 233 NA NA NA NA NA NA
Garcia-ClosaM-1997 Mixed populations 416/446 75 4 337 73 4 369 NA NA NA NA NA NA
Ishibe N-1997 Mixed(Mexican and African) 171/295 68 12 91 106 35 154 31 7 132 70 20 204
Hong YS-1998 Asia(Korean) 85/63 45 6 34 31 3 29 68 1 16 60 1 2
Taioli E-1998 Mixed populations 105/307 30 9 59 101 18 170 8 1 94 18 0 272
Sugimura H-1998 Asia(Japan) 247/185 NA NA NA NA NA NA 94 28 125 84 7 94
Le Marchand L-1998 Mixed populations 341/456 121 35 183 160 44 250 68 6 263 105 13 335
Xue KX-1999 Asia(china) 103/131 NA NA NA NA NA NA 31 18 54 36 11 36
Hu YL-1999 Asia(china) 59/132 22 15 22 76 22 34 33 7 19 102 9 21
London SJ-2000 Asia(China) 214/669 NA NA NA NA NA NA 39 8 167 130 27 512
Dresler CM-2000 Caucasian(USA) 158/149   37* 121   17* 132 NA NA NA NA NA NA
Song N-2001 Asia(China) 217/404 129 28 60 175 56 173 130 9 78 181 13 210
Ratnasinghe D-2001 Caucasian(USA) 282/324 NA NA NA NA NA NA 36 3 243 48 3 273
Quinones L-2001 Caucasians(Chile) 60/174 29 10 16 38 16 86 35 10 15 52 14 54
Chen S-2001 Asia(china) 106/106 NA NA NA NA NA NA 38 10 58 33 3 70
Xue KX-2001 Asia(china) 106/106 NA NA NA NA NA NA 38 10 58 33 3 33
Yin LH-2002 Asia(china) 84/84 34 13 37 38 18 28 NA NA NA NA NA NA
Zhou XW-2002 Asia(china) 92/98 43 15 34 34 13 51 66 11 15 65 6 65
Cai XL-2003 Asia(china) 91/138 23 36 32 46 39 53 NA NA NA NA NA NA
Kiyohara C-2003 Asia(Japan) 158/259 64 17 77 115 28 116 NA NA NA NA NA NA
Taioli E-2003 Mixed populations 109/424 MspI
110/707exon7
20 5 84 75 4 345 16 1 93 70 2 635
Wang J-2003 Asia(china) 162/181 76 22 64 78 38 65 NA NA NA NA NA NA
Dialyna IA-2003 Caucasians (Greek) 122/178 28 5 89 45 3 130 NA NA NA NA NA NA
Dong CT-2004 Asia(china) 82/91 NA NA NA NA NA NA 36 18 28 32 10 32
Gu YF-2004 Asia(china) 180/224   129 * 51   138* 86 NA NA NA NA NA NA
Liang GY-2004 Asia(china) 152/152 82 20 50 71 11 70 NA NA NA NA NA NA
Chen SD-2004 Asia(china) 58/62 15 23 20 20 18 24 NA NA NA NA NA NA
Yang XR-2004 Asia(China) 200/144 NA NA NA NA NA NA 96 11 90 39 7 98
Sobti RC-2004 Asia(India) 100/76 45 6 49 29 5 42 67 29 4 53 15 8
Wenzlaff AS-2005 Caucasian(USA) 128/181 35 0 93 30 4 116 5#   124 14#   134
Wrensch MR-2005 Mixed populations 371/944 MspI 363/930exon7   166* 205   472* 472   64# 302   219# 711
Ng DP-2005 Asia(Singapore) 126/162 61 22 41 87 19 56 39 13 74 63 7 91
Larsen EJ-2005 Caucasians(Australia) 1050/581 NA NA NA NA NA NA 84 8 958 27 2 552
Raimondi S-2005 Caucasians 165/519 MspI
175/723exon7
  43* 122   102* 417   32# 143   67# 656
Raimondi S-2005-2 Asians 46/138 MspI
60/212 exon7
  28* 18   95* 43   30# 30   96# 116
Sreeja L-2005 Asia(Indian) 146/146 53 22 71 45 8 93 NA NA NA NA NA NA
Adonis M-2005 Mixed populations 57/103 31 11 15 33 26 44 NA NA NA NA NA NA
Belogubova-2006 Caucasians (Russian) 141/450 35 2 104 90 3 357 NA NA NA NA NA NA
Li DR-2006 Asia(china) 150/152 NA NA NA NA NA NA 104 14 32 105 8 105
Pisani P-2006 Asia(Thailand) 211/408 87 55 26 155 78 53 79 10 78 129 23 135
Yang MH-2007 Asia(Korea) 314/349 NA NA NA NA NA NA 116 16 182 111 18 220
Tao WH-2007 Asia(china) 47/94 19 4 24 37 14 43 NA NA NA NA NA NA
Cote ML-2007 Mixed populations 354/440 80 5 269 95 6 339 19 0 326 34 6 400
Xia Y-2008 Asia(china) 58/116 36 5 17 58 18 40 NA NA NA NA NA NA
Qi XS-2008 Asia(china) 53/72 29 7 17 38 11 23 NA NA NA NA NA NA
Yoon KA-2008 Asia(Korea) 213/213 NA NA NA NA NA NA 76 10 127 87 10 116
Gallegos-Arreola-2008 Mixed populations 222/248 NA NA NA NA NA NA 91 40 91 104 11 133
Shah PP-2008 Asia(India) 200/200   94* 106   63* 137   67# 133   44# 156
Kumar M-2009 Asia(India) 93/253 NA NA NA NA NA NA 17 3 73 40 3 210
Cote ML-2009 Mixed populations 502/523 109 14 373 110 7 402 38 0 464 32 2 489
Honma HN-2009 Mixed populations 200/264 76 11 113 94 9 161 NA NA NA NA NA NA
Klinchid J-2009 Asia(Thailand) 85/82   66* 19   66* 16   47# 33   42# 38
Timofeeva MN-2009 Caucasians (German) 619/1264 NA NA NA NA NA NA 248 61 260 545 117 585
Shaffi SM-2009 Asia(India) 109/163   81* 28   85* 78 NA NA NA NA NA NA
Jin Y-2010 Asia(China) 124/154   71* 79   70* 80 NA NA NA NA NA NA
Wright CM-2010 Caucasians (Australian) 1040/784 219 24 797 128 10 646 103 8 929 40 3 741
  1. NA, not applicable; *, the number of the combined of TypeB and TypeC genetypes;#, the number of the combined Ile/Val and Val/Val genotypes.