From: CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review
Subgroup analysis | MspI genotype | exon7 genotype | ||||
---|---|---|---|---|---|---|
 | Contrast | studies | OR(95%) Ph | Contrast | studies | OR(95%) Ph |
Total | Type C vs Type A (TypeB+TypeC) vs Type A | 49 | 1.26(1.12-1.42) 0.003 1.20(1.13-1.28) 0.000 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 40 | 1.24(1.09-1.42) 0.004 1.15(1.07-1.24) 0.000 |
Ethnicity | Â | Â | Â | Â | Â | Â |
Asian | Type C vs Type A (TypeB+TypeC) vs Type A | 26 | 1.24(1.12-1.43) 0.004 1.30(1.17-1.44) 0.002 | Val/Val vs Ile/Ile (Ile/Val +Val/Val)vs Ile/Ile | 22 | 1.22(1.16-1.59) 0.016 1.21(1.09-1.34) 0.000 |
Caucasian | Type C vs Type A (TypeB+TypeC) vs Type A | 11 | 1.25(1.09-1.36) 0.053 1.35(1.18-1.54) 0.046 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 10 | 1.24(1.17-1.43) 0.090 1.28(1.12-1.45) 0.000 |
Mixed population | Type C vs Type A (TypeB+TypeC) vs Type A | 12 | 1.05(0.89-1.28) 0.140 1.02(0.92-1.14) 0.330 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 8 | 0.84(0.77-1.03) 0.090 0.92(0.79-1.06) 0.001 |
Histological type | Â | Â | Â | Â | Â | Â |
SCC | Type C vs Type A (TypeB+TypeC) vs Type A | 13 | 1.87(1.58-2.14)0.005 1.93(1.62-2.30) 0.000 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 11 | 1.38(1.12-1.66) 0.004 1.42(1.18-1.70) 0.007 |
AC | Type C vs Type A (TypeB+TypeC) vs Type A | 12 | 1.34(1.14-1.56)0.014 1.20(1.01-1.43) 0.000 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 10 | 0.90(0.72-1.08) 0.005 0.95(0.79-1.15) 0.001 |
SCLC | Type C vs Type A (TypeB+TypeC) vs Type A | 8 | 0.96(0.70-1.26)0.864 1.06(0.77-1.45) 0.976 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 7 | 0.84(0.68-1.08)0.068 0.78(0.53-1.14) 0.039 |
Gender | Â | Â | Â | Â | Â | Â |
Male | Type C vs Type A (TypeB+TypeC) vs Type A | 3 | 1.39(1.23-1.79) 0.210 1.46(1.07-1.98) 0.380 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 7 | 1.18(0.92-1.35) 0.360 1.15(0.96-1.39) 0.298 |
Female | Type C vs Type A (TypeB+TypeC) vs Type A | 7 | 0.92(0.84-1.16) 0.003 0.85(0.71-1.02) 0.000 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | 3 | 1.29(1.08-1.51) 0.000 1.24(1.05-1.47) 0.002 |
Smoking status | Â | 13 | Â | Â | 10 | Â |
Smokers | Type C vs Type A (TypeB+TypeC) vs Type A | Â | 1.62(1.33-1.96) 0.000 1.75(1.44-2.13) 0.003 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | Â | 1.84(1.36-2.08) 0.003 1.62(1.24-2.11) 0.004 |
Non-smokers | Type C vs Type A (TypeB+TypeC) vs Type A | Â | 1.18(0.96-1.48) 0.086 1.09(0.90-1.33) 0.114 | Val/Val vs Ile/Ile (Ile/Val +Val/Val) vs Ile/Ile | Â | 1.18(0.96-1.38) 0.080 1.07(0.88-1.31) 0.002 |