Skip to main content

Table 2 Summary ORs for various contrasts of CYP1A1 MspI and exon7 gene polymorphisms in this meta-analysis

From: CYP1A1 MspI and exon7 gene polymorphisms and lung cancer risk: An updated meta-analysis and review

Subgroup analysis MspI genotype exon7 genotype
  Contrast studies OR(95%) Ph Contrast studies OR(95%) Ph
Total Type C vs Type A
(TypeB+TypeC) vs Type A
49 1.26(1.12-1.42) 0.003
1.20(1.13-1.28) 0.000
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
40 1.24(1.09-1.42) 0.004
1.15(1.07-1.24) 0.000
Ethnicity       
Asian Type C vs Type A
(TypeB+TypeC) vs Type A
26 1.24(1.12-1.43) 0.004
1.30(1.17-1.44) 0.002
Val/Val vs Ile/Ile
(Ile/Val +Val/Val)vs Ile/Ile
22 1.22(1.16-1.59) 0.016
1.21(1.09-1.34) 0.000
Caucasian Type C vs Type A
(TypeB+TypeC) vs Type A
11 1.25(1.09-1.36) 0.053
1.35(1.18-1.54) 0.046
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
10 1.24(1.17-1.43) 0.090
1.28(1.12-1.45) 0.000
Mixed population Type C vs Type A
(TypeB+TypeC) vs Type A
12 1.05(0.89-1.28) 0.140
1.02(0.92-1.14) 0.330
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
8 0.84(0.77-1.03) 0.090
0.92(0.79-1.06) 0.001
Histological type       
SCC Type C vs Type A
(TypeB+TypeC) vs Type A
13 1.87(1.58-2.14)0.005
1.93(1.62-2.30) 0.000
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
11 1.38(1.12-1.66) 0.004
1.42(1.18-1.70) 0.007
AC Type C vs Type A
(TypeB+TypeC) vs Type A
12 1.34(1.14-1.56)0.014
1.20(1.01-1.43) 0.000
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
10 0.90(0.72-1.08) 0.005
0.95(0.79-1.15) 0.001
SCLC Type C vs Type A
(TypeB+TypeC) vs Type A
8 0.96(0.70-1.26)0.864
1.06(0.77-1.45) 0.976
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
7 0.84(0.68-1.08)0.068
0.78(0.53-1.14) 0.039
Gender       
Male Type C vs Type A
(TypeB+TypeC) vs Type A
3 1.39(1.23-1.79) 0.210
1.46(1.07-1.98) 0.380
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
7 1.18(0.92-1.35) 0.360
1.15(0.96-1.39) 0.298
Female Type C vs Type A
(TypeB+TypeC) vs Type A
7 0.92(0.84-1.16) 0.003
0.85(0.71-1.02) 0.000
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
3 1.29(1.08-1.51) 0.000
1.24(1.05-1.47) 0.002
Smoking status   13    10  
Smokers Type C vs Type A
(TypeB+TypeC) vs Type A
  1.62(1.33-1.96) 0.000
1.75(1.44-2.13) 0.003
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
  1.84(1.36-2.08) 0.003
1.62(1.24-2.11) 0.004
Non-smokers Type C vs Type A
(TypeB+TypeC) vs Type A
  1.18(0.96-1.48) 0.086
1.09(0.90-1.33) 0.114
Val/Val vs Ile/Ile
(Ile/Val +Val/Val) vs Ile/Ile
  1.18(0.96-1.38) 0.080
1.07(0.88-1.31) 0.002
  1. Ph P value of Q-test for heterogeneity test