Figure 4
Genetic instability analyzed by array CGH in Case #13. Primary bone tumors showed the genetic instability of 26 DCNAs of 287 clones (c), whereas a metastatic lymph node showed 57 DCNAs in 287 clones (d). The genetic aberration of metastatic lymph node is relatively high compared with a primary bone tumor. a: A radiogram of humerus showing the osteosclerotic change by the osteosarcoma. b: Histological appearance showing atypical cells with osteoid formation. c: A study of microarray CGH (primary tumor). d: A study of microarray CGH (metastatic tumor).