Figure 5
Exogenous AM promoted cell migration with increased integrin α5β1 activation. FACS flow analysis showed increased expression of integrin α5 in AM treated HO8910 cells than in non-treated cells (A). Blocking antibody of integrin α5β1 inhibited the effect of AM on cell migration (B). Exogenous AM promoted FAK and paxillin phosphorylation at different time point (C). Blocking antibody of integrin α5β1 abolished the AM promotion on FAK, paxillin phosphorylation (D).