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Table 3 Prognostic factors in multivariate Cox proportional-hazards regression models for RFS

From: Prognostic value of RKIP and p-ERK in gastric cancer

 

Univariatea)

Multivariate 1b)

Multivariate 2c)

 

5-yr RFSd)

p

HR

95%CI

p

HR

95% CI

p

Age

        

   > 70

73

       

   ≦ 70

51

0.094

      

Gender

        

   female

74

       

   male

56

0.22

      

Histopathology

        

   differentiated

79

 

1.0

  

1.0

  

   undifferentiated

42

0.001

2.2

1.1 - 4.4

0.035

2.1

1.0 - 4.2

0.043

Depth of invasion

        

   T1/2

93

 

1.0

  

1.0

  

   T3/4

46

0.002

4.8

1.0 - 23

0.048

4.7

1.0 - 22

0.048

Lymph node metastasis

        

   negative (N0)

83

 

1.0

  

1.0

  

   positive (N1/2/3)

48

0.002

1.6

0.59 - 4.5

0.34

1.6

0.59 - 4.5

0.35

RKIP

        

   positive

66

 

1.0

     

   negative

44

0.003

1.7

0.89 - 3.3

0.11

   

pMEK

        

   negative

62

       

   positive

55

0.79

      

pERK

        

   negative

75

 

1.0

     

   positive

49

0.054

2.0

0.93 - 4.2

0.078

   

Combined expression

        

   RKIP(+) or p-ERK(-)

69

    

1.0

  

   RKIP(-) and p-ERK(+)

33

< 0.001

   

2.4

1.3 - 4.6

0.008

  1. a) log-rank test
  2. b) analysed factors: Histopathology, Depth of invasion, Lymph node metastasis, RKIP, and pERK
  3. c) analysed factors: Histopathology, Depth of invasion, Lymph node metastasis, and Combined expression of RKIP and pERK
  4. d) the rate of 5-year relapse free survival
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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