Influence of conditioned medium from adipose tissue in the proliferation of LNCaP cells. Analyses were conducted using conditioned medium of periprostatic (PP) and visceral (VIS) adipose tissue from 10 subjects after explants and stromal-vascular fraction primary cultures. A. Influence of adipose tissue-derived CM in LNCaP cell proliferation, in comparison with control (0% CM) (* P < 0.05 and ** P < 0.01, relative to control, two-sided post-hoc Dunnett test). B. Comparison of the effect of CM from distinct adipose tissue depot and fractions in LNCaP proliferation after tissue weight normalization (** P < 0.01 and *** P < 0.0001 between groups, independent samples t-test). CM, conditioned medium. SVF, stromal-vascular fraction. PP, periprostatic; VIS, visceral.