Figure 1
From: Claudin-5 is involved in breast cancer cell motility through the N-WASP and ROCK signalling pathways
Patients with breast cancer and high levels of Claudin-5 have reduced survival. (a) Patients with high levels of Claudin-5 transcript correlates with a significantly shorter survival (p = 0.004). (b) Claudin-5 mRNA level was increased in human breast tumors. (c) Claudin-5 transcript levels were increased in patients with poor prognosis (NPI 3). (d) Higher levels of Claudin-5 transcripts were seen in at TNM1. (e) Claudin-5 transcript levels were decreased in grade 3 when compared to grade 1 and grade 2. (f) Patients who died of breast cancer had higher levels of Claudin-5 transcript when compared with patients who remained disease free.