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Table 3 Consistently reported down-regulated miRNAs ( n= 28) in profiling studies (lung cancer tissue versus normal)

From: Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

miRNA namea No. of studies with same direction (reference) Total number of tissue samples tested Subset of studies with fold change
    No. of studies Total number of tissue samples tested Mean fold change Range
miR-126 10 (19,21,25,26,27, 28,29,30,31,32) 587 8 311 0.33 0.00 - 0.69
miR-30a 8 (19,21,25,26,27,28,29,31) 339 7 271 0.36 0.04 - 0.61
miR-451 6 (19,21,25,27,28,29) 265 6 265 0.37 0.01 - 0.53
miR-486-5p 5 (19,22,26,27,28) 437 4 369 0.39 0.13 - 0.53
miR-30d 5 (21,25,28,29,31) 154 5 154 0.34 0.08 - 0.57
miR-145 4 (26,28,30,32) 362 2 86 0.23 0.09 - 0.38
miR-143 4 (21,28,30,32) 310 3 102 0.33 0.13 - 0.59
miR-139-5p 3 (22,27,29) 301 3 301 0.55 0.40 - 0.64
miR-126* 3 (21,25,30) 280 2 72 0.33 0.20 - 0.45
miR-140-3p 3 (26,27,28) 179 2 111 0.29 0.17 - 0.42
miR-138 3 (25,26,32) 164 2 96 0.64 0.56 - 0.72
miR-30b 3 (25,28,29) 132 3 132 0.41 0.11 - 0.58
miR-486 3 (25,29,32) 126 3 126 0.44 0.34 - 0.53
miR-101 3 (21,27,31) 87 3 87 0.34 0.24 - 0.48
miR-125a 2 (24,30) 279 0 - - -
miR-198 2 (27,30) 273 1 65 0.25 -
miR-144* 2 (22,27) 271 2 271 0.31 0.14 - 0.48
miR-140 2 (30,32) 248 1 40 0.66 -
miR-218 2 (22,32) 246 2 246 0.61 0.60 - 0.62
miR-32 2 (20,30) 220 0 - - -
miR-338-3p 2 (26,27) 133 1 65 0.20 -
miR-99a 2 (27,28) 111 2 111 0.31 0.20 - 0.42
miR-195 2 (26,29) 98 1 30 0.53 -
miR-497 2 (26,29) 98 1 30 0.66 -
miR-30c 2 (25,29) 86 2 86 0.58 0.54 - 0.61
miR-130a 2 (21,27) 81 2 81 0.46 0.45 - 0.46
miR-16 2 (28,29) 76 2 76 0.37 0.18 - 0.57
miR-139 2 (29,32) 70 2 70 0.53 0.49 - 0.58
  1. a The asterisk is part of the miRNA nomenclature system and is not linked to any footnote specific to this table.