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Table 3 Consistently reported down-regulated miRNAs ( n= 28) in profiling studies (lung cancer tissue versus normal)

From: Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

miRNA namea

No. of studies with same direction (reference)

Total number of tissue samples tested

Subset of studies with fold change

   

No. of studies

Total number of tissue samples tested

Mean fold change

Range

miR-126

10 (19,21,25,26,27, 28,29,30,31,32)

587

8

311

0.33

0.00 - 0.69

miR-30a

8 (19,21,25,26,27,28,29,31)

339

7

271

0.36

0.04 - 0.61

miR-451

6 (19,21,25,27,28,29)

265

6

265

0.37

0.01 - 0.53

miR-486-5p

5 (19,22,26,27,28)

437

4

369

0.39

0.13 - 0.53

miR-30d

5 (21,25,28,29,31)

154

5

154

0.34

0.08 - 0.57

miR-145

4 (26,28,30,32)

362

2

86

0.23

0.09 - 0.38

miR-143

4 (21,28,30,32)

310

3

102

0.33

0.13 - 0.59

miR-139-5p

3 (22,27,29)

301

3

301

0.55

0.40 - 0.64

miR-126*

3 (21,25,30)

280

2

72

0.33

0.20 - 0.45

miR-140-3p

3 (26,27,28)

179

2

111

0.29

0.17 - 0.42

miR-138

3 (25,26,32)

164

2

96

0.64

0.56 - 0.72

miR-30b

3 (25,28,29)

132

3

132

0.41

0.11 - 0.58

miR-486

3 (25,29,32)

126

3

126

0.44

0.34 - 0.53

miR-101

3 (21,27,31)

87

3

87

0.34

0.24 - 0.48

miR-125a

2 (24,30)

279

0

-

-

-

miR-198

2 (27,30)

273

1

65

0.25

-

miR-144*

2 (22,27)

271

2

271

0.31

0.14 - 0.48

miR-140

2 (30,32)

248

1

40

0.66

-

miR-218

2 (22,32)

246

2

246

0.61

0.60 - 0.62

miR-32

2 (20,30)

220

0

-

-

-

miR-338-3p

2 (26,27)

133

1

65

0.20

-

miR-99a

2 (27,28)

111

2

111

0.31

0.20 - 0.42

miR-195

2 (26,29)

98

1

30

0.53

-

miR-497

2 (26,29)

98

1

30

0.66

-

miR-30c

2 (25,29)

86

2

86

0.58

0.54 - 0.61

miR-130a

2 (21,27)

81

2

81

0.46

0.45 - 0.46

miR-16

2 (28,29)

76

2

76

0.37

0.18 - 0.57

miR-139

2 (29,32)

70

2

70

0.53

0.49 - 0.58

  1. a The asterisk is part of the miRNA nomenclature system and is not linked to any footnote specific to this table.