Figure 8
Representative H&E photomicrographs of carcinoma in-situ (top panel) and invasive SCC (lower panel). Top panel, markedly thickened epithelial layer with multiple layers of cells and dysplasia (nuclear atypia, black arrow). White arrow points to the rounded outline without breaching the basement membrane, denoting the pre-invasive phase (ie., carcinoma in-situ). Lower panel, micrograph showing irregular nests (black arrows) of proliferating epithelial cells with cellular atypia and nuclear polymorphism. The tumor nests (black arrows) are seen infiltrating into the stroma as single cells and irregular nests (black arrows) (original magnification 200x).