Skip to main content

Table 3 Univariate and multivariate analyses of the relationship of CD44+/CD24-/low tumor cells to disease-free survival

From: CD44+/CD24- phenotype contributes to malignant relapse following surgical resection and chemotherapy in patients with invasive ductal carcinoma

Variable

Univariate analysis

Multivariate analysis

HR

95% CI

p-value

HR

95% CI

p-value

CD44+/CD24-/low tumor cells

High

2.144

1.321-3.479

0.002

1.963

1.163-3.313

0.012

Low

1.000

  

1.000

  

ER status

Positive

0.826

0.524-1.304

0.412

1.425

0.731-2.776

0.298

Negative

1.000

  

1.000

  

PR status

Positive

0.500

0.312–0.800

0.004

0.192

0.088–0.420

0.001

Negative

1.000

  

1.000

  

Her2 status

Positive

0.966

0.614–1.521

0.882

0.692

0.317–1.513

0.357

Negative

1.000

  

1.000

  

Basal-like feature*

Present

2.731

0.461-1.393

0.007

3.902

1.402-10.859

0.009

Absent

1.000

  

1.000

  

TNM stage

Stage III/IV

1.989

0.814–2.626

0.029

1.820

1.051–3.151

0.033

Stage I/II

1.000

  

1.000

  

Lymph node involvement

Absent

0.724

0.427-1.227

0.230

1.081

0.540-2.164

0.827

Present

1.000

  

1.000

  

Age (years)

≥ 50

1.047

0.681–1.610

0.883

1.062

0.627–1.799

0.822

< 50

1.000

  

1.000

  
  1. Abbreviations: HR, hazard ratio estimated from Cox proportional hazard regression model; CI, confidence interval of the estimated HR. ER, estrogen receptor; PR, progesterone receptor; Her2, human epidermal growth factor receptor 2.
  2. * Immunohistochemically negative for both SR and Her2.