Table 4 Analysis for combinational biomarkers
Variables | Combinations | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Mutation+ | Mutation- | Mutation+ | Mutation- | Mutation+ | Mutation- | Mutation+ | Mutation- | P | ||
1068+ | 1068+ | 1068- | 1068- | 1068+ | 1068+ | 1068- | 1068- | - | ||
1173+ | 1173+ | 1173+ | 1173+ | 1173- | 1173- | 1173- | 1173- | - | ||
Total | 35(22.4) | 42(26.9) | 5(3.2) | 8(5.1) | 30(19.2) | 19(12.2) | 2(1.3) | 15(9.6) | - | |
ORR | CR + PR | 16(45.7) | 7(16.7) | 1(20.0) | 1(12.5) | 20(66.7) | 5(26.3) | 0 | 0 | <0.001 |
DCR | CR + PR + SD | 28(80.0) | 26(61.9) | 3(60.0) | 1(12.5) | 29(96.7) | 17(89.5) | 1(50.0) | 8(53.3) | <0.001 |
PD | 7(20.0) | 16(38.1) | 2(40.0) | 7(87.5) | 1(3.3) | 2(10.5) | 1(50.0) | 7(46.7) | ||
PFS | Median (months) | 6.3 | 3.1 | 4.6 | 1 | 12.8 | 6.6 | 0.4 | 1.4 | <0.001 |