Lymph nodes adjacent and contralateral to tumor-bearing sentinel lymph nodes in oral melanoma-bearing mice. (A) Lymph nodes (LNs) (arrow) adjacent to tumor-bearing sentinel LNs (SLNs) (arrowhead) showing enlargement. (B) Enlarged LNs (arrow) contralateral to tumor-bearing SLNs (arrowhead). (C) Changes in weight of LNs adjacent and contralateral to tumor-bearing SLNs. Columns, mean; bar, standard error. *, P<0.05 relative to the control. (D) Photograph of adjacent LN (arrow) showing medullary hyperplasia to tumor-bearing SLN (t-SLN; arrowhead). Scale bar = 50 μm. (E) Photograph of LNs contralateral to tumor-bearing SLN. Both LNs show medullary hyperplasia. Scale bar = 50 μm.