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Figure 7 | Journal of Experimental & Clinical Cancer Research

Figure 7

From: Tumor-induced lymphangiogenesis in cervical lymph nodes in oral melanoma-bearing mice

Figure 7

Lymphangiogenesis in lymph nodes adjacent and contralateral to tumor-bearing sentinel lymph nodes. (A), (B) Double immunofluorescent images of tyrosinase-related protein 1 (TRP-1; green) and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1; red) in lymph nodes (LNs) adjacent (A) and contralateral (B) to tumor-bearing sentinel LNs (SLNs), showing an increase in LYVE-1-positive sinuses in the medulla. aLN, adjacent lymph node; cLN, contralateral lymph node; arrowhead, TRP-1-positive melanoma cells. Scale bar = 50 μm. (C) Measurement of LYVE-1-positive lymphatic sinus area in LNs adjacent and contralateral to tumor-bearing SLNs. Columns, mean; bar, standard error. *, P<0.001 relative to controls.

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