Figure 3
TNKS1 inhibition induces cell apoptosis in SH-SY5Y and SK-N-SH cells. A, E. The figures of SH-SY5Y and SK-N-SH cells stained with Annexin V in control group and XAV939 group. B, G. The bar graph of average percent of apoptotic cells in control group and XAV939 group. *P < 0.05 compared to controls. C, F. The morphology of apoptotic nuclei was observed by Hoechst 33342 staining. The arrows point at the apoptotic nuclei. D, H. The bar graph of percentages of apoptotic cells in control group and XAV939 group. *P < 0.05 compared to controls. The apoptosis of SH-SY5Y cells was indicated by figures A, B, C and D, while that of SK-N-SH cells was indicated by figures E, F, G and H.