Figure 1

Changes of survivin, p53, Bcl-2 and Ki-67 in liver metastases pre- and post-⁹⁰Y-RE. A. The histogram shows the significant reduction of the positivity of survivin (from 92% to 54%; p = 0.06), p53 (from 100% to 69%; p = 0.05) and Bcl-2 (from 46% to 31%; p = 0.05) expression in liver metastases pre- and post-⁹⁰Y-RE therapy. A limited, not significant decrease in proliferation index by Ki-67 (from 77% to 61%) is also evident. B. Immunohistochemical staining of 3 autologous liver metastases sampled pre- and post- therapy showing a strong decrease in survivin (a) p53 (b), and Bcl-2 (c) immunoreactions.