Table 2 Copy number genomic alterations that predominant in NSCLC from non-smoking Asians with mutant EGFR compared to TCGA database
Region of Chromosome | NSCLC with mutant EGFR (n=8) | NSCLC from TCGA data base (n=56) | Potential target gene(s) |
|---|---|---|---|
Gain of 1p36.32-36.31 | 8/9(89) | 15/56(27%) | AJAP1 |
Gain of Ch2p | Fewer alteration | More alterations | Large fragment |
Gain of Ch3q | Fewer alteration | More alterations | Large fragment |
Loss of 6q22.3-27 | Fewer alteration | More alterations | Large fragment |
Loss of 9p21.3 | 1/9(11%) | 19/56(34%) | p14,p15,p16 |
Gain of 15q23-26.3 | 0/9(0%) | 10/56(18%) | Large fragment |
Gain of 19q12 | 6/9(70%) | 6/56(11%) | Cyclin E1 |
Gain of 20q11.21 | 0/9(0%) | 26/56(46%) | BCL2L1, TPX2, MYLK2, DUSP15 |