Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma

Table 1 Peritumoral α-SMA expression according to characteristics of 224 hepatitis B virus related HCC patients

Characteristics		Low expression (n = 44) (cell numbers ≤ 72)	High expression (n = 180) (cell numbers > 72)	p
Gender	Male	40	152	0.342
Gender	Female	4	28	0.342
Age(years)	≤51	24	94	0.867
Age(years)	>51	20	86	0.867
ALT(U/L)	≤75	35	162	0.700
ALT(U/L)	>75	9	18	0.700
AFP(ng/ml)	≤20	18	68	0.731
AFP(ng/ml)	>20	26	112	0.731
Cirrhosis	Yes	37	155	0.810
Cirrhosis	No	7	25	0.810
Vascular invasion	Yes	8	46	0.446
Vascular invasion	No	36	134	0.446
Encapsulation	Yes	24	96	1.000
Encapsulation	No	20	84	1.000
Number	Single	37	155	0.810
Number	Multiple	7	25	0.810
Size	≤5	38	122	0.015
Size	>5	6	58	0.015
Differentiation	I-II	41	128	0.002
Differentiation	III-IV	3	52	0.002
TNM stage	I	37	121	0.028
	II-III	7	59

α-SMA: α-smooth muscle actin; AFP: alpha fetoprotein; ALT, alanine aminotransferase; TNM, tumor-node-metastasis.

ISSN: 1756-9966