Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma

Table 2 Prognostic factors for survival and recurrence

Factor	OS			TTR
	Univariate	Multivariate		Univariate	Multivariate
	P	HR (95% CI)	P	P	HR (95% CI)	P
AFP (≤20 v >20 ng/ml)	NS		NA	0.018		NS
Tumor number (single v multiple)	0.032	2.199(1.209-4.003)	0.010	NS		NA
Vascular invasion(yes v no)	0.008		NS	0.014	1.690(1.011-2.823)	0.045
Tumor encapsulation (yes v no)	NS		NA	0.048		NS
TNM stage (IvII- III)	0.001	2.175(1.326-3.566)	0.002	0.004	1.834(1.111-3.028)	0.018
Peritumoral α-SMA density (low v high)	0.013	2.559(1.101-5.949)	0.029	0.001	2.424(1.040-5.650)	0.040

Univariate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model. Abbreviations: OS: overall survival; TTR: time to recurrence; HR: Hazard Ratio; CI: confidence interval; AFP: alpha fetoprotein; TNM: tumor-node-metastasis; α-SMA: α-smooth muscle actin; NA: not adopted; NS: not significant.

ISSN: 1756-9966