Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma

Table 3 Prognostic factors for early and late recurrence

Factor	Early recurrence			Late recurrence
	Univariate	Multivariate		Univariate	Multivariate
	P	HR (95% CI)	P	P	HR (95% CI)	P
AFP(ng/ml)(≤20 v >20)	0.006	1.752(1.035-2.966)	0.037	NS		NA
Tumor size (≤5.0 v >5.0)	<0.001	2.591(1.631-4.116)	<0.001	NS		NA
Vascular invasion(yes v no)	0.011		NS	NS		NA
TNM stage (IvII- III)	0.012		NS	NS		NA
Peritumoral α-SMA density (low v high)	0.002	3.148(1.263-7.844)	0.014	NS		NA

Univariate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model. Abbreviations: HR: Hazard Ratio; CI: confidence interval; AFP: alpha fetoprotein; TNM: tumor-node-metastasis; α-SMA: α-smooth muscle actin; NA: not adopted; NS: not significant.

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