Figure 1

Immumohistochemical staining of ADAM-17 in renal carcinoma tissues. A: Normal kidney tissue stained by ADAM-17. B: Renal carcinoma tissue (stage-III) with ADAM-17 concentrated around the cytomembrane stained red (arrowed). C: Expression of Notch1 and HES-1 protein as measured by Western blot analysis after treatment with Marimastat or DAPT, or a media alone control, in 786-O cells. D: Expression of Notch1 and HES-1 protein levels by Western blot after treatment with Marimastat or DAPT, or a media alone control, in OS-RC-2 cells.