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Table 3 Result of Transwell assay in 786-o cell treated by different inhibitors

From: Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma

 

Marimastat

DAPT

Concentration

  

1μmol/L

7.80±1.64

15.8±3.19

2μmol/L

3.4±0.55

10.8±1.72

3μmol/L

1.2±0.84

4.4±0.55

Control

34.2±1.50

31.8±3.19

  1. In the Transwell assay, the number of 786-o cells penetrating Matrigel decreased with the increasing concentration of Marimastat and DAPT, whereas Marimastat had more effect under the same concentration(P<0.05), which indicates that MARIMASTAT is more capable of thwarting the invasion of 786-o cells.
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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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