High expression of IL-17 and IL-17RE associate with poor prognosis of hepatocellular carcinoma

Table 3 Prognostic factors for early and late recurrence

Factor	Early recurrence			Late recurrence
	Univeriate	Multivariate		Univeriate	Multivariate
	P	HR (95% CI)	P	P	HR (95% CI)	P
AFP(ng/ml)(≤20 v >20)	0.018	1.457(1.012-2.098)	0.043	NS		NA
Tumor size(cm) (≤5.0 v >5.0)	<0.001	1.799(1.272-2.544)	0.001	NS		NA
Vascular invasion(yes v no)	<0.001	1.472(1.032-2.101)	0.033	NS		NA
TNM stage (I v II- III)	0.001	1.423(1.003-2.020)	0.048	NS		NA
Peritumoral density (low v high) IL-17RE	<0.001	1.604(1.129-2.280)	0.008	0.001	2.148(1.158-3.986)	0.015
Intratumoral density (low v high)
IL-17RE	0.001		NS	0.007		NS
Il-17	0.004		NS	0.034		NS
Combination of IL-17RE &IL-17	<0.001	1.430(1.227-1.666)	<0.001	<0.001	1.458(1.093-1.947)	0.010

Univeriate analysis: Kaplan-Meier method; multivariate analysis: Cox proportional hazards regression model.
Abbreviations: HR, Hazard Ratio; CI, confidence interval; AFP, alpha fetoprotein; TNM, tumor-node-metastasis;IL-17(RE), interleukin-17(receptor E); NA, not adopted; NS, not significant.

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