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Table 6 Comparison of pharmacokinetic parameters in dogs and humans after taurolidine infusion

From: Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma

Parameter Dog Human
Cmax (μg/mL) 140.5 ± 40.3 95.8 ± 21.8
t1/2 (hr) 3.4 ± 0.4 1.7 ± 0.1
AUC (μg h/mL) 455 ± 200 249.2 ± 58.4
CL (L/hr/kg) 0.40 ± 0.20 1.28*
Vss (L/kg) 1.39 ± 0.85 3.18*
  1. *Estimated in humans based on a 66 kg body weight from the data published by Stendel et al. 2007. Numbers in humans are after 3 infusions of taurolidine, 2 hours long each with a one hour interval between [21] whereas the numbers in dogs are after a single 2 hour long infusion.