Table 6 Comparison of pharmacokinetic parameters in dogs and humans after taurolidine infusion
From: Pharmacokinetic study and evaluation of the safety of taurolidine for dogs with osteosarcoma
Parameter | Dog | Human |
|---|---|---|
Cmax (μg/mL) | 140.5 ± 40.3 | 95.8 ± 21.8 |
t1/2 (hr) | 3.4 ± 0.4 | 1.7 ± 0.1 |
AUC (μg h/mL) | 455 ± 200 | 249.2 ± 58.4 |
CL (L/hr/kg) | 0.40 ± 0.20 | 1.28* |
Vss (L/kg) | 1.39 ± 0.85 | 3.18* |