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Table 3 The mean (range) and p-values for Dmean, Dmax of both heart and LAD

From: Dosimetric and clinical advantages of deep inspiration breath-hold (DIBH) during radiotherapy of breast cancer

  

Conventional fractionation

Hypofractionation

Organ

Parameter

DIBH

FB

p-value

DIBH

FB

p-value

Heart

Dmax (Gy)(*)

5.00

29.19

0.0015

3.85

24.75

0.0025

(2.00 – 10.00)

(5.00 – 52.00)

(1.00 – 8.00)

(3.00 – 46.00)

Dmean (Gy)

1.24

1.68

0.0106

0.84

1.14

0.0106

(1.03 – 1.43)

(1.29 – 2.48)

(0.70 – 0.97)

(0.87 – 1.68)

V20(**) (%)

0.00

0.39

0.1574

0.00

0.33

0.1644

(0.00 -0.00)

(0.00 -1.61)

(0.00-0.00)

(0.00 – 1.40)

V40(**) (%)

0.00

0.16

0.1719

0.00

0.07

0.1708

(0.00 -0.00)

(0.00 – 0.70)

(0.00-0.00)

(0.00 -3.00)

LAD

Dmax (Gy)(*)

4.25

19.62

0.0488

3.10

16.75

0.0479

(2.00 – 11.00)

(3.00 – 52.00)

(1.00 – 8.00)

(2.00 – 46.00)

Dmean (Gy)

2.74

9.01

0.0914

1.86

6.12

0.9140

(0.80 – 7.55)

(1.45 – 28.05)

(0.54 – 5.13)

(0.99 - 19.07)

  1. (*)EQD2 values using α/β =2.5 Gy for Pericardites in heart an for LAD.
  2. (**)EQD2 values using α/β =3.0 Gy for long term Mortality.