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Table 1 Patient characteristics and comparative analysis of principal clinical features consistent with LS between the three groups

From: Early-onset colorectal cancer patients without family history are “at very low risk” for lynch syndrome

Characteristic No family history (group A, n = 70) Am. II§§criteria (group B, n = 40) Family history without Am.II criteria (Group C, n = 7) P-value§
Median age (years), range 42 (20–50) 45 (28–50) 39 (36–46)  
Gender distribution     
  M 29 18 3
  F 48 22 4
Right sided CRC (%) 16 (22.9) 21 (52.5) 2 0,006
Multiple primary cancer (%) 4 (5.7) 12 (30) 0 <0.0001**
Extracolonic cancer (%) 2 (2.9) (thyroid, pancreas) 10 (25) (3 endometrium, 2 breast, 2 kidney, 1 stomach, 2 ovary, 3 sebaceous skin tumours)* 0 <0.001**
Metachronous cancer (%) 4 (5.7) 10 (25) 0 0.007**
Synchronous cancer (%) 2 (2.9) 6 (15) 0 0.04**
  1. *4 cases were multiple primary cancer.
  2. **AvsB.
  3. §Fisher’s Exact test was used, to evaluate associations between the variables.
  4. §§AM.II: Amsterdam II.