Table 1 Patient characteristics and comparative analysis of principal clinical features consistent with LS between the three groups
Characteristic | No family history (group A, n = 70) | Am. II§§criteria (group B, n = 40) | Family history without Am.II criteria (Group C, n = 7) | P-value§ |
|---|---|---|---|---|
Median age (years), range | 42 (20–50) | 45 (28–50) | 39 (36–46) | |
Gender distribution | ||||
M | 29 | 18 | 3 | |
F | 48 | 22 | 4 | |
Right sided CRC (%) | 16 (22.9) | 21 (52.5) | 2 | 0,006 |
Multiple primary cancer (%) | 4 (5.7) | 12 (30) | 0 | <0.0001** |
Extracolonic cancer (%) | 2 (2.9) (thyroid, pancreas) | 10 (25) (3 endometrium, 2 breast, 2 kidney, 1 stomach, 2 ovary, 3 sebaceous skin tumours)* | 0 | <0.001** |
Metachronous cancer (%) | 4 (5.7) | 10 (25) | 0 | 0.007** |
Synchronous cancer (%) | 2 (2.9) | 6 (15) | 0 | 0.04** |