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Table 1 Characteristics of study cohorts

From: miR-33a is up-regulated in chemoresistant osteosarcoma and promotes osteosarcoma cell resistance to cisplatin by down-regulating TWIST

Group Discovery cohort Validation cohort
Chemoresistant OS (n=6) Control (n=6) Chemoresistant OS (n=35) Control (n=35)
Age (years)
Mean±SD 9.6±4.2 9.6±4.2 9.9±4.9 10.1±5.2
Range 7–14 7–14 6–16 6–16
Gender n (%)
Male 3 (50) 3 (50) 21 (60) 23 (66)
Female 3 (50) 3 (50) 14 (40) 12 (34)
Tumor stage n (%)
Stage IIA 2 (33) 2 (33) 8 (23) 7 (20)
Stage IIB 2 (33) 2 (33) 13 (37) 13 (37)
Stage III 2 (33) 2 (33) 14 (40) 15 (43)
Body mass index (kg/m2) 17.5±4.0 18.2±4.1 17.7±3.8 18.3±4.0
Tumor necrosis (%) 94.1±2.8 70.8±9.2* 93.5±3.6 73.6±12.2*
  1. Note: OS osteosarcoma. *p < 0.05 vs Chemoresistant OS.