NE promotes angiogenesis in vivo . A) Representative photographs of the B16F1 tumor sections examined by immunohistochemical staining for VEGF (× 200 magnification). B) Immunohistochemical staining for CD31 (× 200 magnification). C) The bar chart showing MVD calculated by CD31 immunoreactivity. Each bar represents the average vessel number of each group, expressed as the mean ± SD. *, P ≤ 0.05. D) The photograph of immunohistochemical staining in negative control slides for VEGF. E) Immunohistochemical staining for β1-AR on the slides of B16F1 cells (× 200 magnification). F) Immunohistochemical staining for β2-AR (× 200 magnification).