High STC2 expression predicts inferior outcomes in NPC patients. Survival data were analyzed and plotted using the Kaplan–Meier method. Patients were classified into STC2 negative or positive according to STC2 immunohistochemistry. *: P <0.05. A. Local regional failure-free survival (LRFS); B. Distant metastasis-free survival (DMFS); C. Overall Survival (OS); and D. Progression-free survival (PFS).